Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade

@inproceedings{Kandimalla2017BioactiveFO,
  title={Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade},
  author={Raghuram Kandimalla and Suvakanta Dash and Sanjeeb Kalita and Bhaswati Choudhury and Sandeep Malampati and R. K. Vidyabati Devi and Muthiah Ramanathan and Narayan Chandra Talukdar and Jibon Kotoky},
  booktitle={Front. Cell. Neurosci.},
  year={2017}
}
The present study explains the neuroprotective ability of bioactive fractions of Annona reticulata bark (ARB) and Ziziphus jujuba root bark (ZJ) along with insulin against diabetic neuropathy. By using different solvents of increasing polarity ARB and ZJ were undergone for bioactive guided fractionation. The neuroprotective ability of the all the plant fractions were tested against H2O2 induced toxicity in SHSY5Y neuroblastoma cell lines and DRG neuronal cells. Among all the fractions tested… CONTINUE READING
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