Bioactive Flavonoids as ABC Transporters Inhibitors for Reversion of Multidrug Resistance in Cancer

@inproceedings{Sastry2014BioactiveFA,
  title={Bioactive Flavonoids as ABC Transporters Inhibitors for Reversion of Multidrug Resistance in Cancer},
  author={Nagendra Sastry},
  year={2014}
}
Drug resistance is a common clinical problem that occurs in patients suffering from infectious diseases and in patients suffering from cancer [1,2]. Multidrug resistance (MDR) is frequently associated with over expression of ABC transporters. This class of membrane proteins uses the energy of ATP hydrolysis to actively pump metabolites or xenobiotics out of cells against a concentration gradient. If members of this family are over expressed in chemotherapy-resistant tumor cells, they cause a… CONTINUE READING