Bioactivation of zearalenone by porcine hepatic biotransformation.

  title={Bioactivation of zearalenone by porcine hepatic biotransformation.},
  author={Hassan Malekinejad and Roel Franciscus Maas-Bakker and Johanna Fink-Gremmels},
  journal={Veterinary research},
  volume={36 5-6},
Zearalenone (ZEA) is a resorcylic acid lactone derivative produced by various Fusarium species that are widely found in food and feeds. The structure of zearalenone is flexible enough to allow a conformation able to bind to mammalian oestrogen receptors, where it acts as an agonist. Using oestrogen-dependent Human Breast Cancer (MCF-7) cells, the oestrogenic activity of zearalenone and its derivatives were compared using 17 beta-oestradiol as a positive control. The results obtained demonstrate… CONTINUE READING
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