Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.

@article{Ross1994BioactivationOQ,
  title={Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.},
  author={David D. Ross and Howard D. Beall and Robert D. Traver and David Siegel and Roger M. Phillips and Neil W. Gibson},
  journal={Oncology research},
  year={1994},
  volume={6 10-11},
  pages={493-500}
}
Because of the elevated DT-diaphorase (DTD) activity in certain tumors such as human nonsmall cell lung cancer (NCSLC), DTD is a potential target on which to base the development of new antitumor compounds. Mitomycin C is the most effective single agent used for the therapy of NSCLC and is metabolized and bioactivated by DTD. Mitomycin C is a poor substrate for DTD, however, and its metabolism is pH-dependent. We have therefore focused on identifying more efficient substrates for DTD. We have… CONTINUE READING

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