Bioactivation of dimethylnitrosamine in intrasanguinous host-mediated assay and its association with in vitro mutagenesis assays.

@article{Bakshi1980BioactivationOD,
  title={Bioactivation of dimethylnitrosamine in intrasanguinous host-mediated assay and its association with in vitro mutagenesis assays.},
  author={K P Bakshi and David J. Brusick},
  journal={Mutation research},
  year={1980},
  volume={72 1},
  pages={79-89}
}
These studies have revealed the usefulness of in vivo intrasanguine host-mediated assay (HMA) to detect point mutations. Mutations were found to occur at a significant rate in Salmonella typhimurium G-46 employed as indicator organisms recovered from liver, lung, kidney and spleen of DMN-treated animals compared to negative control animals. These… CONTINUE READING