Bioactivation of N-substituted N'-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3.

@article{Onderwater2006BioactivationON,
  title={Bioactivation of N-substituted N'-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3.},
  author={R. C. A. Onderwater and Allan E Rettie and Jan N. M. Commandeur and Nico P E Vermeulen},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2006},
  volume={36 7},
  pages={645-57}
}
Enzyme kinetic parameters of the bioactivation of thiourea-containing compounds by human flavin-containing monooxygenase enzymes (FMOs) FMO1 and FMO3 were investigated. A microtitre-based adaptation of methodology described for the thiourea-dependent oxidation of thiocholine was used to determine the turnover of thiourea-containing compounds by human FMO1 and FMO3. The results show that major differences in enzyme kinetic parameters for N-substituted N'-(4-imidazole-ethyl)thiourea exist between… CONTINUE READING