BioMEMS devices for drug delivery

@article{Nuxoll2009BioMEMSDF,
  title={BioMEMS devices for drug delivery},
  author={Eric E Nuxoll and Ronald A. Siegel},
  journal={IEEE Engineering in Medicine and Biology Magazine},
  year={2009},
  volume={28},
  pages={31-39}
}
  • E. Nuxoll, R. Siegel
  • Published 13 January 2009
  • Biology, Engineering
  • IEEE Engineering in Medicine and Biology Magazine
Successful therapeutic outcomes following the administration of drugs, including small molecules and large biomolecules, require not only the selection of a proper drug but also its delivery to the proper site of action, with proper temporal presentation. Drug delivery is an extremely broad area of research, as each molecule presents its own absorption, distribution, metabolism, excretion, and toxicology (ADMET) profile. Moreover, timing of drug release may affect the efficacy of a… 

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References

SHOWING 1-10 OF 153 REFERENCES
Small-scale systems for in vivo drug delivery
TLDR
Micro- and nanotechnologies are enabling the design of novel methods such as radio-frequency addressing of individual molecules or the suppression of immune response to a release device, but current challenges include the need to balance the small scale of the devices with the quantities of drugs that are clinically necessary.
Bioadhesive Microdevices for Drug Delivery: A Feasibility Study
TLDR
This study demonstrates the fabrication of prototype reservoir containing microparticles and a surface chemistry protocol that can be used to bind lectin via avidin-biotin interactions to siliconmicroparticles, and in vitro studies show enhanced bioadhesion of these lectin conjugated microp articles.
Integrated microsystems for controlled drug delivery.
In vivo release from a drug delivery MEMS device.
Multi-pulse drug delivery from a resorbable polymeric microchip device
TLDR
Biodegradable polymeric microchips were fabricated that released four pulses of radiolabelled dextran, human growth hormone or heparin in vitro that retained on average 96 ± 12% of its bioactivity.
Microsystems for drug and gene delivery
TLDR
Recent progress in microdevices for delivering therapeutic agents, including microneedles, DNA transfection schemes, and intravascular drug and gene delivery systems are reviewed.
Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications.
TLDR
A multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells is shown, based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores.
Bioadhesive poly(methyl methacrylate) microdevices for controlled drug delivery.
...
...