Bio-imaging of metals in a mouse model of Alzheimer's disease by laser ablation inductively coupled plasma mass spectrometry

@inproceedings{Matusch2012BioimagingOM,
  title={Bio-imaging of metals in a mouse model of Alzheimer's disease by laser ablation inductively coupled plasma mass spectrometry},
  author={Andreas Matusch and Johanna Sabine Becker},
  year={2012}
}
Quantitative mass spectrometry imaging (MSI) of metals in biological tissue sections by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) using matrix-matched laboratory standards has been established previously. Here an improved calibration strategy is proposed, correcting for variable section thickness by normalization of sample and standard ion intensities to the average 13 C + ion signal of all ablated sample and standard material, respectively. Altered metal… CONTINUE READING

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