Bio-antimutagenic activities of vitamin B6 in E. coli and mouse peripheral blood cells.

@article{Shimoi1992BioantimutagenicAO,
  title={Bio-antimutagenic activities of vitamin B6 in E. coli and mouse peripheral blood cells.},
  author={Kayoko Shimoi and E Akaiwa and Nobuko Mori and Masaaki Sano and Yoshimasa Nakamura and I. N. Tomita},
  journal={Mutation research},
  year={1992},
  volume={266 2},
  pages={205-13}
}
Pyridoxal (PL) and pyridoxal 5'-phosphate (PLP) showed a marked bio-antimutagenic effect on UV-induced mutagenesis in E. coli B/r WP2, but not in the DNA excision repair-deficient strain WP2suvrA under the condition where no cellular toxicity was observed. No delay in the first cell division was seen on post-treatment with PL after UV irradiation. PL reduced not only UV- but 4-nitroquinoline-1-oxide-induced mutation, while it was ineffective in N-methyl-N'-nitro-N-nitrosoguanidine- or gamma-ray… CONTINUE READING