Bio-Revitalization: Effects of NASHA on Genes Involving Tissue Remodeling

  title={Bio-Revitalization: Effects of NASHA on Genes Involving Tissue Remodeling},
  author={Anna Avantaggiato and Ambra Girardi and Annalisa Palmieri and Michele Pascali and Francesco Carinci},
  journal={Aesthetic Plastic Surgery},
BackgroundThe “non-animal stabilized hyaluronic acid” (NASHA) is a widely used product in bio-revitalization injective procedures in esthetic medicine. The present research aimed to quantitatively evaluate the therapeutic effect of one of the more used bio-revitalization products on cultured dermal fibroblasts. RT-PCR was used for gene expression profiling of some proteins known to be relevant in skin homeostasis.MethodsHuman dermal fibroblasts were seeded on a culture medium enriched with a… Expand
3 Citations
Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies.
The mechanistic behavior of HA pertaining to its biological synthesis and degradation and the administration of some noteworthy and recent HA based formulations through different routes for application in various physiological conditions are discussed. Expand
Light therapy has proven to be effective in reducing the damage oral tissue and promotes healing of tissue and is therefore recommended in surgery and dentistry (1, 2). In particular light-emittingExpand
Direct brow lifting: Specific indications for a simplified approach to eyebrow ptosis
  • M. Pascali, I. Bocchini, +4 authors D. Quarato
  • Medicine
  • Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • 2016
The direct brow lift technique in bald men and with a high anterior hairline provides excellent and long-lasting results. Expand


Comparison of Bio-Revitalizing Injective Products: A Study on Skin Fibroblast Cultures.
Differences among medical devices regarding their effects on cultured skin fibroblasts over time are compared by using RT-PCR and a panel of genes involved in dermal integrity, and HA concentration seems to be inversely correlated to elastin gene activation. Expand
Role of Antioxidants in Dermal Aging: An In Vitro Study by q-RT-PCR
Upregulation of elastin-, hyaluronic acid-, and GDF6-encoding genes supports the evidence of clinical improvement induced by NAC biostimulation in the prevention and correction of skin aging. Expand
Biostimulation and biorevitalization: effects on human skin fibroblasts
Abstract Introduction Aesthetic medicine uses many injective techniques; biostimulation (BS) and biorevitalization (BR) are among these. The term BS indicates stimulation of the anabolic functions ofExpand
Differential regulation of hyaluronan metabolism in the epidermal and dermal compartments of human skin by UVB irradiation.
There is a complex temporal and spatial regulation of HA-metabolism in skin in response to UVB irradiation, and immunohistochemical staining for HA in human skin 24-hours post-irradiation demonstrated an increased epidermal HA, but a decrease in the dermal compartment. Expand
Immunogenicity Studies of Cosmetically Administered Nonanimal‐Stabilized Hyaluronic Acid Particles
BACKGROUND Hypersensitivity resulting from humoral or cellular immunologic mechanisms is the least well-documented of adverse events associated with dermal fillers. OBJECTIVE Humoral and cellularExpand
Therapeutic potential of matrix metalloproteinases in Duchenne muscular dystrophy
Modulation of the activity of MMPs improves myofiber regeneration and enhances the efficacy of transplantation and engraftment of muscle progenitor cells in dystrophic muscle in mouse models of DMD. Expand
Rejuvenating Influence of a Stabilized Hyaluronic Acid–Based Gel of Nonanimal Origin on Facial Skin Aging
Micropuncture placement of NASHA can exert a rejuvenating effect on facial skin, and skin elasticity and surface roughness improved significantly. Expand
Integrating Animal Models and In Vitro Tissue Models to Elucidate the Role of Desmosomal Proteins in Diseases
New approaches that combine in vitro and in vivo models to elucidate the role of desmosomal gene deregulation in human skin diseases such as AEC are discussed. Expand
Disentangling the multifactorial contributions of fibronectin, collagen and cyclic strain on MMP expression and extracellular matrix remodeling by fibroblasts.
  • Y. Zhang, Z. Lin, +4 authors V. Vogel
  • Chemistry, Medicine
  • Matrix biology : journal of the International Society for Matrix Biology
  • 2014
It is proposed that the appearance of collagen might start to steer HFFs towards homeostasis, as it decreased both MMP secretion and the tension of Fn matrix fibrils as assessed by Fluorescence Resonance Energy Transfer. Expand
Stabilized hyaluronic acid-based gel of non-animal origin for skin rejuvenation: face, hand, and décolletage.
This was the first study that used a micropuncture injector device for injection of NASHA gel, and reveals that this is a promising treatment option for rejuvenation of the skin. Expand