Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area.

@article{Sparta2013BingeEP,
  title={Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area.},
  author={Dennis R. Sparta and Frederic Woodward Hopf and Stuart L. Gibb and Saemi L. Cho and Garret D. Stuber and Robert O Messing and Dorit Ron and Antonello Bonci},
  journal={Alcoholism, clinical and experimental research},
  year={2013},
  volume={37 10},
  pages={
          1680-7
        }
}
BACKGROUND Corticotropin releasing factor (CRF) and urocortin play an important role in many stress responses and also can regulate ethanol (EtOH) intake. Adaptations in CRF signaling in the central amygdala promote EtOH consumption after long-term EtOH intake in dependent animals and also after brief periods of binge EtOH intake. Thus, even brief episodes of EtOH consumption can alter the function of the CRF system, allowing CRF to regulate EtOH intake. Here, we examined whether brief binge… CONTINUE READING
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