Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.

@article{Branson2003BingeEA,
  title={Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.},
  author={Ruth Branson and Natascha Potoczna and John G. Kral and Klaus-Ulrich Lentes and Margret R. Hoehe and Fritz F. Horber},
  journal={The New England journal of medicine},
  year={2003},
  volume={348 12},
  pages={1096-103}
}
BACKGROUND Obesity, a multifactorial disease caused by the interaction of genetic factors with the environment, is largely polygenic. A few mutations in these genes, such as in the leptin receptor (LEPR) gene and melanocortin 4 receptor (MC4R) gene, have been identified as causes of monogenic obesity. METHODS We sequenced the complete MC4R coding region, the region of the proopiomelanocortin gene (POMC) encoding the alpha melanocyte-stimulating hormone, and the leptin-binding domain of LEPR… CONTINUE READING
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