Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.


BACKGROUND Obesity, a multifactorial disease caused by the interaction of genetic factors with the environment, is largely polygenic. A few mutations in these genes, such as in the leptin receptor (LEPR) gene and melanocortin 4 receptor (MC4R) gene, have been identified as causes of monogenic obesity. METHODS We sequenced the complete MC4R coding region… (More)