Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action.

  title={Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action.},
  author={Claudia Lindtner and Thomas Scherer and Elizabeth Zieliński and Nika Filatova and Martin Fasshauer and Nicholas K. Tonks and Michelle A. Puchowicz and Christoph Buettner},
  journal={Science translational medicine},
  volume={5 170},
Individuals with a history of binge drinking have an increased risk of developing the metabolic syndrome and type 2 diabetes. Whether binge drinking impairs glucose homeostasis and insulin action is unknown. To test this, we treated Sprague-Dawley rats daily with alcohol (3 g/kg) for three consecutive days to simulate human binge drinking and found that these rats developed and exhibited insulin resistance even after blood alcohol concentrations had become undetectable. The animals were… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 68 references

A meta - analysis on the impact of alcohol dependence on short - term restingstate heart rate variability : Implications for cardiovascular risk

  • A. L. Mark P. van de Borne, N. Montano, D. Mion, V. K. Somers
  • Alcohol . Clin . Exp . Res .
  • 2013

Effect of caloric restriction

  • M. García-San Frutos, T. Fernández-Agulló, +7 authors inflammation in hypothalamic insulin resistance associated with ageing
  • Mech. Ageing Dev. 133, 489–497
  • 2012
1 Excerpt

Insights from mouse models of tissue-specific PTP1B deficiency

  • R. C. Tsou, K. K. Bence, The genetics of PTPN1, obesity
  • J. Obes. 2012, 926857
  • 2012
1 Excerpt

The Korea National Health and Nutrition Examination Survey 2008

  • K. Lee, Gender-specific relationships between alcohol drinking patterns, metabolic syndrome
  • Public Health Nutr. 15, 1917–1924
  • 2012
1 Excerpt

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