Binge drinking disturbs hepatic microcirculation after transplantation: prevention with free radical scavengers.
@article{Zhong1999BingeDD, title={Binge drinking disturbs hepatic microcirculation after transplantation: prevention with free radical scavengers.}, author={Zhi Zhong and Gavin E. Arteel and Henry D. Connor and Peter Schemmer and Shu-chuan Chou and James A. Raleigh and Ronald P. Mason and John J. Lemasters and Ronald G. Thurman}, journal={The Journal of pharmacology and experimental therapeutics}, year={1999}, volume={290 2}, pages={ 611-20 } }
Disturbances in hepatic microcirculation increase graft injury and failure; therefore, this study evaluates the effects of ethanol on microcirculation after liver transplantation. Donor rats were given one dose of ethanol (5 g/kg) by gavage 20 h before explantation, and grafts were stored in University of Wisconsin solution for 24 h before implantation. Acute ethanol treatment decreased 7-day survival of grafts from about 90 to 30%, increased transaminase release nearly 4-fold, and decreased…
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