• Corpus ID: 18957736

Binge drinking disturbs hepatic microcirculation after transplantation: prevention with free radical scavengers.

@article{Zhong1999BingeDD,
  title={Binge drinking disturbs hepatic microcirculation after transplantation: prevention with free radical scavengers.},
  author={Zhi Zhong and Gavin E. Arteel and Henry D. Connor and Peter Schemmer and Shu-chuan Chou and James A. Raleigh and Ronald P. Mason and John J. Lemasters and Ronald G. Thurman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={290 2},
  pages={
          611-20
        }
}
Disturbances in hepatic microcirculation increase graft injury and failure; therefore, this study evaluates the effects of ethanol on microcirculation after liver transplantation. Donor rats were given one dose of ethanol (5 g/kg) by gavage 20 h before explantation, and grafts were stored in University of Wisconsin solution for 24 h before implantation. Acute ethanol treatment decreased 7-day survival of grafts from about 90 to 30%, increased transaminase release nearly 4-fold, and decreased… 
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Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats.
Role of free radicals in failure of fatty liver grafts caused by ethanol.
ICAM-1 Upregulation in Ethanol-Induced Fatty Murine Livers Promotes Injury and Sinusoidal Leukocyte Adherence after Transplantation
TLDR
Increased ICAM-1 expression in ethanol-treated fatty livers predisposes to leukocyte adherence after LT, which leads to a disturbed microcirculation, oxidative stress and graft injury.
Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers.
Ischemia-reperfusion Injury after Canine Liver Allo-transplantation: The Effect of Gadolinium Chloride.
TLDR
Kupffer cell blockage using the Gadolinium chloride might be an effective way of reducing ischemia reperfusion injury, however, this effect was not evident in the early stages of reperfusions.
Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver.
Repeated whiskey binges promote liver injury in rats fed a choline-deficient diet.
Intrahepatic microcirculatory disorder, parenchymal hypoxia and NOX4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and D-galactosamine-induced acute liver failure in rats
TLDR
The results revealed that the apoptotic cells in zone 3 were a result of hypoxic conditions induced by intrahepatic microcirculatory disorder, and were not induced by activated macrophages, and may contribute to the progression of hepatocyte apoptosis.
Acute alcohol intoxication and gadolinium chloride attenuate endotoxin-induced release of CC chemokines in the rat.
Binge ethanol exposure increases liver injury in obese rats.
TLDR
The data indicate that binge drinking increases apoptosis and liver injury in obese rats more than in lean controls and suggest that the injury may involve oxidative and nitrosative damage.
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References

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TLDR
Data indicate that survival is poorer and graft injury is greater in fatty livers from ethanol-treated rats and gadolinium chloride minimized graft damage, most likely by improving hepatic microcirculation and diminishing lipid peroxidation.
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TLDR
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TLDR
The hypothesis that a brief rinse of liver grafts with warm buffer markedly improves the hepatic microcirculation, leading to dramatic improvement in graft survival is supported, and a brief warm rinse may be useful clinically in liver transplantation is demonstrated.
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TLDR
Ethananol plays a major role in hepatic reperfusion injury, most likely via mechanisms involving free radicals, and increased hepatic fat content alone plays only a minor role, probably by causing slight disturbances in the hepatic microcirculation.
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TLDR
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TLDR
Although parenchymal cell function was in the normal range in livers stored in the cold for 24 hr, liver grafts stored for 6 hr and longer in Euro-Collins solution could not be transplanted successfully and it is concluded that viability of paren chymal cells in liver grafting prior to transplantation is a poor parameter to predict the outcome of transplantation.
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TLDR
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