Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis

Abstract

HFE, the protein that is mutated in hereditary haemochromatosis, binds to the transferrin receptor (TfR). Here we show that wild-type HFE and TfR localize in endosomes and at the basolateral membrane of a polarized duodenal epithelial cell line, whereas the primary haemochromatosis HFE mutant, and another mutant with impaired TfR-binding ability accumulate… (More)
DOI: 10.1038/35046611

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