Binding to Ia protects an immunogenic peptide from proteolytic degradation.

Abstract

A 34 amino acid hen egg-white lysozyme (HEL) peptide was designed and synthesized to investigate if an immunogenic peptide once bound to an Ia molecule becomes proteolytically inaccessible. The determinant recognized by T cells, HEL(52-61) was composed of L-amino acids whereas the 12 amino acid extension on each side of this core were composed of D-epimers… (More)

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Cite this paper

@article{Donermeyer1989BindingTI, title={Binding to Ia protects an immunogenic peptide from proteolytic degradation.}, author={David L. Donermeyer and P. M. Allen}, journal={Journal of immunology}, year={1989}, volume={142 4}, pages={1063-8} }