Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis.

@article{Oda2014BindingTC,
  title={Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis.},
  author={Toshiaki Oda and Shuhei Chiba and Tomoaki Nagai and Kensaku Mizuno},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2014},
  volume={19 12},
  pages={927-40}
}
Primary cilia are formed by extending the microtubule-based axoneme from the mother centriole-derived basal body. Recruitment of Tau tubulin kinase-2 (TTBK2) to the mother centriole and subsequent removal of CP110 and its interactor Cep97 are crucial for the initiation of ciliogenesis. We analyzed the roles of two TTBK2-binding proteins, EB1 and Cep164, in centriolar localization of TTBK2. TTBK2 bound EB1 and Cep164 through its SxIP motifs and a proline-rich motif, respectively. Using TTBK2… CONTINUE READING
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