Binding studies of terbutaline sulfate to calf thymus DNA using multispectroscopic and molecular docking techniques.

@article{Bi2015BindingSO,
  title={Binding studies of terbutaline sulfate to calf thymus DNA using multispectroscopic and molecular docking techniques.},
  author={Shuyun Bi and Tingting Zhao and Yu Wang and Huifeng Zhou and Bo Pang and Tingting Gu},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2015},
  volume={150},
  pages={921-7}
}
The interaction of terbutaline sulfate (TS) with calf thymus DNA (ctDNA) were investigated by fluorescence quenching, UV-vis absorption, viscosity measurements, ionic strength effect, DNA melting experiments and molecular docking. The binding constants (Ka) of TS to ctDNA were determined as 4.92×10(4), 1.26×10(4) and 1.16×10(4) L mol(-1) at 17, 27 and 37 °C, respectively. Stern-Volmer plots suggested that the quenching of fluorescence of TS by ctDNA was a static quenching. The absorption… CONTINUE READING
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