Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression

@article{Ito2001BindingSO,
  title={Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression},
  author={A. Ito and K. Handa and D. A. Withers and M. Satoh and S. Hakomori},
  journal={FEBS Letters},
  year={2001},
  volume={498}
}
  • A. Ito, K. Handa, +2 authors S. Hakomori
  • Published 2001
  • Chemistry, Medicine
  • FEBS Letters
  • Previous studies indicate that expression of higher gangliosides in renal cell carcinoma (RCC) is correlated with metastatic potential, particularly in the lung. Out of five major gangliosides in RCC, three disialogangliosides (disialogalactosylgloboside, IV3NeuAcIII6NeuAcLc4, and IV4GalNAcIV3NeuAcIII6NeuAcLc4) bind strongly to siglec7, which is expressed highly in monocytes and natural killer cells. Out of other gangliosides tested, 2→6 sialylparagloboside, GD3, GD2, and GT1b, but not other… CONTINUE READING
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