Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.

@article{Stebbins2001BindingSF,
  title={Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.},
  author={Elizabeth G. Stebbins and Daria Mochly-Rosen},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={29644-50}
}
Identification of selective anchoring proteins responsible for specialized localization of specific signaling proteins has led to the identification of new inhibitors of signal transduction, inhibitors of anchoring protein-ligand interactions. RACK1, the first receptor for activated C kinase identified in our lab, is a selective anchoring protein for betaII protein kinase C (betaIIPKC). We previously found that at least part of the RACK1-binding site resides in the C2 domain of betaIIPKC (Ron… CONTINUE READING

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