Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease.

@article{Verdier2004BindingSO,
  title={Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease.},
  author={Yann Verdier and Botond Penke},
  journal={Current protein & peptide science},
  year={2004},
  volume={5 1},
  pages={
          19-31
        }
}
The binding of amyloid beta peptides (Abeta) to plasma membranes appears to be a promising point of intervention in the events leading to the development of Alzheimer's disease (AD). This binding has been studied as regards the direct toxicity of Abeta on neurons, and the activation of a local inflammation phase involving microglia. By virtue of its structure, Abeta is able to bind to a variety of biomolecules, including lipids, proteoglycans and proteins. This review focuses on the membrane… CONTINUE READING

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