Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.

@article{RadaIglesias2005BindingSF,
  title={Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.},
  author={Alvaro Rada-Iglesias and Ola Wallerman and Christoph M. Koch and Adam Ameur and Stefan Enroth and Gayle K. Clelland and Kenneth Wester and Sarah J. Wilcox and Oliver M Dovey and Peter F. Ellis and Vicki L Wraight and Keith D. James and Rob C. Andrews and Cordelia Langford and Pawandeep Dhami and Nigel P. Carter and David Vetrie and Fredrik Pont{\'e}n and Jan Komorowski and Ian Dunham and Claes Wadelius},
  journal={Human molecular genetics},
  year={2005},
  volume={14 22},
  pages={3435-47}
}
We present a detailed in vivo characterization of hepatocyte transcriptional regulation in HepG2 cells, using chromatin immunoprecipitation and detection on PCR fragment-based genomic tiling path arrays covering the encyclopedia of DNA element (ENCODE) regions. Our data suggest that HNF-4alpha and HNF-3beta, which were commonly bound to distal regulatory elements, may cooperate in the regulation of a large fraction of the liver transcriptome and that both HNF-4alpha and USF1 may promote H3… CONTINUE READING

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Antibody-based proteomics for human tissue profiling.

Molecular & cellular proteomics : MCP • 2005
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