Binding sites for [3H]2-OXO-quazepam in the brain of the cat: Evidence for heterogeneity of benzodiazepine recognition sites

@article{Giorgi1989BindingSF,
  title={Binding sites for [3H]2-OXO-quazepam in the brain of the cat: Evidence for heterogeneity of benzodiazepine recognition sites},
  author={Osvaldo Giorgi and Maria Giuseppa Corda and Ivana Gritti and Massimo Mariotti and Ennio Ongini and Giovanni Biggio},
  journal={Neuropharmacology},
  year={1989},
  volume={28},
  pages={715-718}
}
8 Citations
Properties of selective type I benzodiazepine receptor ligands
Conformational studies on zolpidem, 2-oxoquazepam, and ICI 190,622, three type I selective benzodiazepine receptor ligands, are presented. The semiempirical quantum mechanical AM1 technique was used,
Hydrolysis of 2-oxoquazepam in alkaline solution.
TLDR
Kinetics of the hydrolysis reaction in acetonitrile/water mixture was studied by reversed-phase HPLC analysis as a function of water content, NaOH concentration, temperature, and ionic strength.
Quazepam: Hypnotic Efficacy and Side Effects
  • A. Kales
  • Medicine, Psychology
    Pharmacotherapy
  • 1990
TLDR
Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance.

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