Binding sites for [3H]2-OXO-quazepam in the brain of the cat: Evidence for heterogeneity of benzodiazepine recognition sites

@article{Giorgi1989BindingSF,
  title={Binding sites for [3H]2-OXO-quazepam in the brain of the cat: Evidence for heterogeneity of benzodiazepine recognition sites},
  author={Osvaldo Giorgi and Maria Giuseppa Corda and Ivana Gritti and Massimo Mariotti and Ennio Ongini and Giovanni Biggio},
  journal={Neuropharmacology},
  year={1989},
  volume={28},
  pages={715-718}
}
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8 Citations

8 Citations

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Conformational studies on zolpidem, 2-oxoquazepam, and ICI 190,622, three type I selective benzodiazepine receptor ligands, are presented. The semiempirical quantum mechanical AM1 technique was used,…
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Kinetics of the hydrolysis reaction in acetonitrile/water mixture was studied by reversed-phase HPLC analysis as a function of water content, NaOH concentration, temperature, and ionic strength.
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Quazepam: Hypnotic Efficacy and Side Effects
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Quazepam is a benzodiazepine hypnotic that can be useful in the adjunctive pharmacologic treatment of insomnia and is more effective with short‐term use, and with continued use it maintains its efficacy in contrast to both of these drugs which show rapid development of tolerance.

References

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TLDR
Describing the binding of radiolabeled CL to membranes from rat cerebellum and suggesting that it binds to the Type 1 BZ receptor in a manner different from that of a BZ drug such as FLU suggest that TPZ drugs may affect the GABA receptor complex in a different or perhaps less extensive way than the BZs.
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TLDR
Hofstee analyses of the shallow inhibition curves seen in hippocampus and cerebral cortex when [3H]FNM binding was inhibited by β‐CCE indicate that β‐ CCE and some other β‐carboline‐3‐carboxylate derivatives interact preferentially with a subclass of receptors, and that the percentage of this subclass is equivalent to the number of receptors labelled by [3h]PrCC.
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