Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection.

@article{Goodman2010BindingSO,
  title={Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection.},
  author={Laura B. Goodman and Sangbom Michael Lyi and Natalie C. Johnson and Javier O. Cifuente and Susan Hafenstein and Colin R Parrish},
  journal={Journal of virology},
  year={2010},
  volume={84 10},
  pages={4969-78}
}
Canine parvovirus (CPV) and its relative feline panleukopenia virus (FPV) bind the transferrin receptor type 1 (TfR) to infect their host cells but show differences in the interactions with the feline and canine TfRs that determine viral host range and tissue tropism. We changed apical and protease-like domain residues by introducing point mutations and adding or removing glycosylation signals, and we then examined the interactions of those mutant TfRs with the capsids. Most substitutions had… CONTINUE READING

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