Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements.

Abstract

The dendritic cell receptor DC-SIGN mediates pathogen recognition by binding to glycans characteristic of pathogen surfaces, including those found on HIV. Clustering of carbohydrate-binding sites in the receptor tetramer is believed to be critical for targeting of pathogen glycans, but the arrangement of these sites remains poorly understood. Surface force… (More)
DOI: 10.1073/pnas.0901783106

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@article{Menon2009BindingsiteGA, title={Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements.}, author={Sindhu Menon and Kenneth Rosenberg and Sarah A. Graham and Eliot M Ward and M Evangeline Taylor and Kurt Drickamer and Deborah E. Leckband}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2009}, volume={106 28}, pages={11524-9} }