Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus.

@article{Linstedt2000BindingRO,
  title={Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus.},
  author={Adam D. Linstedt and Stephen A. Jesch and Anil Mehta and Tae Hoon Lee and Rafael Garc{\'i}a-Mata and David Spencer Nelson and Elizabeth S. Sztul},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 14},
  pages={10196-201}
}
By forming a molecular tether between two membranes, p115, giantin, and GM130 may mediate multiple Golgi-related processes including vesicle transport, cisternae formation, and cisternal stacking. The tether is proposed to involve the simultaneous binding of p115 to giantin on one membrane and to GM130 on another membrane. To explore this model, we tested for the presence of the putative giantin-p115-GM130 ternary complex. We first mapped p115-binding site in giantin to a 70-amino acid coiled… CONTINUE READING

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