Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein.

@article{Schinkel1993BindingPO,
  title={Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein.},
  author={Alfred H Schinkel and Robert J. Arceci and Jaap Jan J. Smit and E. B. Wagenaar and Frank Baas and M. Dolle and Takashi Tsuruo and E. B. Mechetner and Igor B. Roninson and Piet Borst},
  journal={International journal of cancer},
  year={1993},
  volume={55 3},
  pages={478-84}
}
Monoclonal antibodies (MAbs) recognizing external epitopes of the human MDR1 P-glycoprotein have been used both for the detection of multidrug-resistant cells and as specific inhibitors of P-glycoprotein-mediated multidrug resistance. Using a panel of recently developed transfected or transgenic cell lines containing variants of the human MDR1 and MDR3 P-glycoproteins, we have compared the specificity and binding properties of the previously isolated MAbs MRK16, HYB-241, UIC2 and 4E3, and of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…