Binding preferences of the POU domain protein Brain-4: implications for autoregulation.

  title={Binding preferences of the POU domain protein Brain-4: implications for autoregulation.},
  author={Kanchan Malik and Jong-woo Kim and Amy L Hartman and P. Y. Kim and W Scott Young},
  journal={Brain research. Molecular brain research},
  volume={38 2},
The POU domain-containing transcription factor Brain-4 (Brn-4, RHS-2) was examined for its sites of expression and DNA binding preferences. In the rat, Brn-4 is expressed in 76 and 65% of vasopressin neurons in the paraventricular and supraoptic nuclei, respectively; but in only 10% of corticotropin-releasing factor neurons in the paraventricular nucleus of the hypothalamus. From these data we speculate that genes expressed within vasopressinergic neurons are more likely to be regulated by Brn… CONTINUE READING

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