Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility.

@article{Nguyen1998BindingOU,
  title={Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility.},
  author={Diem H.D. Nguyen and Isa Marte Hussaini and Steven L Gonias},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 14},
  pages={
          8502-7
        }
}
Binding of urokinase-type plasminogen activator (uPA) to its receptor, uPAR, regulates cellular adhesion, migration, and tumor cell invasion. Some of these activities may reflect the ability of uPAR to initiate signal transduction even though this receptor is linked to the plasma membrane only by a glycosylphosphatidylinositol anchor. In this study, we demonstrated that single-chain uPA activates extracellular signal-regulated kinase 1 (ERK1) and ERK2 in MCF-7 breast cancer cells… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 89 CITATIONS, ESTIMATED 48% COVERAGE

Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy.

  • Kidney international
  • 2005
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells.

  • American journal of respiratory cell and molecular biology
  • 2012
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1999
2018

CITATION STATISTICS

  • 14 Highly Influenced Citations