Binding of upstream stimulatory factor 1 to the E-box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells.

@article{Ma2008BindingOU,
  title={Binding of upstream stimulatory factor 1 to the E-box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells.},
  author={Zhongcai Ma and Bongsook Jhun and Sandy Y Jung and Chad K. Oh},
  journal={The Journal of allergy and clinical immunology},
  year={2008},
  volume={121 4},
  pages={1006-1012.e2}
}
BACKGROUND Plasminogen activator inhibitor (PAI)-1 is a key regulator of the fibrinolytic system. PAI-1 levels are markedly elevated in the asthmatic airways. The 4G/5G polymorphism of the PAI-1 gene is associated with allergic asthma. OBJECTIVE To characterize the mechanisms of the 4G/5G-dependent PAI-1 expression in mast cells (MCs), a major source of PAI-1 and key effector cells in asthma. METHODS Transcription of PAI-1 was assessed by transiently transfecting human MC line (HMC-1) cells… CONTINUE READING
5 Extracted Citations
31 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 31 references

Similar Papers

Loading similar papers…