Binding of transforming growth factor-beta 1 to immobilized human alpha 2-macroglobulin.

Abstract

Native alpha 2-macroglobulin (alpha 2M) and alpha 2M-methylamine were immobilized in 96-well microtiter plates. 125I-labeled transforming growth factor-beta 1 (TGF-beta 1) bound to both alpha 2M variants; however, greater binding was observed with alpha 2M-methylamine. Binding of 125I-TGF-beta 1 (0.2 nM) to immobilized alpha 2M-methylamine was inhibited by… (More)

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@article{Webb1992BindingOT, title={Binding of transforming growth factor-beta 1 to immobilized human alpha 2-macroglobulin.}, author={D. J. Webb and Kendall P. Crookston and S. W. Hall and Sara L Gonias}, journal={Archives of biochemistry and biophysics}, year={1992}, volume={292 2}, pages={487-92} }