Binding of the thyroid hormone receptor to a negative element in the basal growth hormone promoter is associated with histone acetylation.

@article{SnchezPacheco2003BindingOT,
  title={Binding of the thyroid hormone receptor to a negative element in the basal growth hormone promoter is associated with histone acetylation.},
  author={Aurora S{\'a}nchez-Pacheco and Ana Aranda},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 41},
  pages={39383-91}
}
Nuclear thyroid hormone receptors (TRs) act as ligand-dependent activators, but paradoxically unliganded TRs can increase transcription of promoters containing negative response elements (nTRE), and hormone binding represses this activation. The rat growth hormone (GH) promoter contains a positive TRE and a nTRE. Ligand-dependent negative regulation mediated by the nTRE could play an important physiological role in restricting GH gene expression in non-pituitary cells that express TRs. With… CONTINUE READING

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A. J. Horlein, A. M. Naar, +7 authors C. K. Glass
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