Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.

@article{Ren2000BindingOT,
  title={Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.},
  author={Jingshan Ren and Charles E. Nichols and Louise E. Bird and Toshiyuki Fujiwara and Hayuki Sugimoto and David I Stuart and David K. Stammers},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 19},
  pages={14316-20}
}
S-1153 (AG1549) is perhaps the most promising non-nucleoside inhibitor of HIV-1 reverse transcriptase currently under development as a potential anti-AIDS drug, because it has a favorable profile of resilience to many drug resistance mutations. We have determined the crystal structure of S-1153 in a complex with HIV-1 reverse transcriptase. The complex possesses some novel features, including an extensive network of hydrogen bonds involving the main chain of residues 101, 103, and 236 of the… CONTINUE READING

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