Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.

@article{Liu2007BindingOT,
  title={Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.},
  author={Sunbin Liu and Ping Li and Olexandr Dybkov and Stephanie Nottrott and Klaus Hartmuth and Reinhard L{\"u}hrmann and Teresa Carlomagno and Markus C Wahl},
  journal={Science},
  year={2007},
  volume={316 5821},
  pages={115-20}
}
Although highly homologous, the spliceosomal hPrp31 and the nucleolar Nop56 and Nop58 (Nop56/58) proteins recognize different ribonucleoprotein (RNP) particles. hPrp31 interacts with complexes containing the 15.5K protein and U4 or U4atac small nuclear RNA (snRNA), whereas Nop56/58 associate with 15.5K-box C/D small nucleolar RNA complexes. We present structural and biochemical analyses of hPrp31-15.5K-U4 snRNA complexes that show how the conserved Nop domain in hPrp31 maintains high RNP… CONTINUE READING

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