Binding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2.

@article{Roccasecca2003BindingOT,
  title={Binding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2.},
  author={R Roccasecca and Helenia Ansuini and Alessandra Vitelli and Annalisa Meola and Elisa Scarselli and Stefano Acali and Monica Pezzanera and Bruno Bruni Ercole and Jane McKeating and Asutosh T. Yagnik and Armin Lahm and Anna Tramontano and Riccardo Cortese and Alfredo Nicosia},
  journal={Journal of virology},
  year={2003},
  volume={77 3},
  pages={1856-67}
}
The envelope glycoprotein E2 of hepatitis C virus (HCV) is the target of neutralizing antibodies and is presently being evaluated as an HCV vaccine candidate. HCV binds to human cells through the interaction of E2 with the tetraspanin CD81, a putative viral receptor component. We have analyzed four different E2 proteins from 1a and 1b viral isolates for their ability to bind to recombinant CD81 in vitro and to the native receptor displayed on the surface of Molt-4 cells. A substantial… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS