Binding of the anticancer drug cis-dichlorodiammineplatinum to 3'(2')-guanosine monophosphate and nucleic acids.

Abstract

The UV-absorption spectral characteristics of cis[Pt(NH3)2(GMP)2]-2 ([Pt(NH3)2 (Guanosine-3'(2')-monophosphate)2]-2) (abbreviated Pt (GMP)2) and cis-[Pt(NH3)2(Guanine)2]+2 (abbreviated Pt(Gua)2) were studied at acidic, neutral and alkaline pH values. The compound Pt(GMP)2 was formed by reacting GMP with cis-Pt(NH3)2Cl2(= cis-platinum) in H2O(pH… (More)

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