Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.

@article{Ghadge1991BindingOT,
  title={Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.},
  author={Ghanashyam D. Ghadge and S Swaminathan and Michael G. Katze and Bayar Thimmapaya},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 16},
  pages={7140-4}
}
In human cells infected with adenovirus, the virus-associated RNA VAI blocks the activation of the interferon-induced double-stranded-RNA-dependent 68-kDa protein kinase (p68) and maintains normal levels of protein synthesis at late times after infection. VAI antagonizes the kinase activity by binding to p68. The structure of VAI consists of two long, base-paired stems connected by a complex short stem-loop structure. Previous work using a series of adenovirus mutants showed that the structural… CONTINUE READING

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