Binding of synthetic peptide TPLVTLFK to nonopioid beta‐endorphin receptor on rat brain membranes

@article{Nekrasova2010BindingOS,
  title={Binding of synthetic peptide TPLVTLFK to nonopioid beta‐endorphin receptor on rat brain membranes},
  author={Y. N. Nekrasova and V. B. Sadovnikov and Y. Zolotarev and E. V. Navolotskaya},
  journal={Journal of Peptide Science},
  year={2010},
  volume={16}
}
The synthetic peptide TPLVTLFK corresponding to the sequence 12–19 of β‐endorphin (referred to as octarphin) was found to bind to high‐affinity naloxone‐insensitive binding sites on membranes isolated from the rat brain cortex (Kd = 2.6 ± 0.2 nM). The binding specificity study revealed that these binding sites were insensitive not only to naloxone but also to α‐endorphin, γ‐endorphin, [Met5]enkephalin, and [Leu5]enkephalin, as well. The [3H]octarphin specific binding with brain membranes was… Expand
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