Binding of rat brain hexokinase to recombinant yeast mitochondria: identification of necessary molecular determinants.

@article{AzoulayZohar1999BindingOR,
  title={Binding of rat brain hexokinase to recombinant yeast mitochondria: identification of necessary molecular determinants.},
  author={Heftsi Azoulay-Zohar and Claude Aflalo},
  journal={Journal of bioenergetics and biomembranes},
  year={1999},
  volume={31 6},
  pages={569-79}
}
The association in vitro of rat brain hexokinase to mitochondria from rat liver or yeast (wild type, porinless, or expressing recombinant human porin) was studied in an effort to identify minimal requirements for each component. A short hydrophobic N-terminal peptide of hexokinase, readily cleavable by proteases, is absolutely required for its binding to all mitochondria. Mammalian porins are significantly cleaved at two positions in putative cytoplasmic loops around residues 110 and 200, as… CONTINUE READING
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