Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC?

@article{Ballieux1994BindingOP,
  title={Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC?},
  author={B E P M Ballieux and Krina T Zondervan and Paul Kievit and E. Christiaan Hagen and Leendert A van Es and Fokko Johannes van der Woude and Mohamed R. Daha},
  journal={Clinical and experimental immunology},
  year={1994},
  volume={97 1},
  pages={52-60}
}
Binding of both proteinase 3 (PR3) and myeloperoxidase (MPO) to endothelial cells (EC) has been suggested to be involved in the vascular damage seen in patients with Wegener's granulomatosis or microscopic polyangiitis. In the present study we investigated in detail the interaction of MPO and PR3 with cultured human umbilical vein endothelial cells (HUVEC) and its matrix products. In addition, we investigated whether interaction of PR3 or MPO with HUVEC monolayers also resulted in antibody… CONTINUE READING
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