Binding of polycyclic aromatic hydrocarbons to polyadenylic acid.

  title={Binding of polycyclic aromatic hydrocarbons to polyadenylic acid.},
  author={A. Morrie Craig and I Isenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={67 3},
A number of polycyclic aromatic hydrocarbons bind to the double-stranded, acid form of polyadenylic acid (poly A). Model building shows that these hydrocarbons may intercalate in the helix, and be well protected from contact with the aqueous medium. Hydrocarbons that are too large to be so protected are found not to bind. A size criterion for the binding of hydrocarbons to poly A therefore exists. This criterion differs from one that was previously found for DNA. The size criteria for DNA and… CONTINUE READING