Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues.

@article{Nomikos2007BindingOP,
  title={Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues.},
  author={Michail Nomikos and Anna Mulgrew-Nesbitt and Payal Pallavi and Gyongyi Mihalyne and Irina N Zaitseva and Karl Swann and F Anthony Lai and Diana Murray and Stuart Mclaughlin},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 22},
  pages={16644-53}
}
Phospholipase C-zeta (PLC-zeta) is a sperm-specific enzyme that initiates the Ca2+ oscillations in mammalian eggs that activate embryo development. It shares considerable sequence homology with PLC-delta1, but lacks the PH domain that anchors PLC-delta1 to phosphatidylinositol 4,5-bisphosphate, PIP2. Thus it is unclear how PLC-zeta interacts with membranes… CONTINUE READING