Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN.

@article{Kimura1994BindingOO,
  title={Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN.},
  author={Yoshimitsu Kimura and K. Sonehara and Etsuro Kuramoto and Toshiyuki Makino and Shigeto Yamamoto and Toshiko Yamamoto and Tohru Kataoka and Tohru Tokunaga},
  journal={Journal of biochemistry},
  year={1994},
  volume={116 5},
  pages={991-4}
}
Specific palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. To study the mechanism of IFN induction by oligonucleotides containing palindromic sequences, we investigated the possible target molecules of the oligonucleotides. Oligo-1, a 30mer single-stranded oligonucleotide with oligoG sequences next to the active palindromic sequence (AACGTT), had more activity than oligonucleotides with oligoA, oligoC, or oligoT… CONTINUE READING

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