Binding of nonintercalative antitumor drugs to DNA-polymers: structural effects of bisquaternary ammonium heterocycles.

@article{Burckhardt1987BindingON,
  title={Binding of nonintercalative antitumor drugs to DNA-polymers: structural effects of bisquaternary ammonium heterocycles.},
  author={G{\"u}nther Burckhardt and C. Zimmer and Bruce C. Baguley},
  journal={Journal of biomolecular structure \& dynamics},
  year={1987},
  volume={4 5},
  pages={
          813-31
        }
}
The binding of the antitumor agents SN-16814 nd SN-13232 to various DNA's in solution was monitored by CD and UV absorption measurements. In addition comparative studies with dA.dT containing duplex DNA of the related ligands SN-6136 and SN-6324 were included with respect to effects of structural variations. In general all four ligands show a dA.dT preference in their binding affinity to DNA. Differences were observed for the reaction of SN-16814 which contains bicyclic ring system: it has a… 
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Sequence Specific Modulation of DNA Restriction Enzyme Cleavage by Minor Groove Binders

The inhibition of the restriction endonuclease PvuII indicates that ligand binding in close vicinity to the cleavage sites is also involved in the enzyme inhibition, and the dAdT-content in proximity to the palindromic sequences of three DraI cutting sites in pUC19 DNA explains why the derivative SN 6053 protects these sequences in different manners.

DNA Binding Properties of Novel Dansylated Distamycin Analogues in Which the Fluorophore is Directly Conjugated to the N-methyl-pyrrole Carboxamide Backbone

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Interaction between antimicrobic ethonium drug and natural DNA

Ethonium interaction with single-chain homopolynucleotides

DNA binding of the nonintercalative ligands SN-6132, SN-6131 and SN-6113: minor variations of the ligand structure may cause changes in the base pair preference.

The DNA binding selectivity of three ligands of a series of antitumor agents of bisquaternary ammonium heterocycles has been investigated by means of CD spectroscopy and melting measurements and it is concluded that the agents SN-6132,SN-6131 and SN- 6113 have relatively high affinity to AT base pair sequences whereas the binding to GC pairs is very low.

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