Binding of non-homologous series of anticancer drugs to cytosine.

Abstract

The interaction of 20 anticancer drugs with cytosine was studied by charge-transfer reversed-phase thin-layer chromatography. The hydrophobicity, the specific hydrophobic surface area and the relative strength of interaction was calculated. Significant linear correlation was found between the hydrophobicity and specific hydrophobic surface area of drugs… (More)

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