Binding of muscimol-conjugated quantum dots to GABAC receptors.

  title={Binding of muscimol-conjugated quantum dots to GABAC receptors.},
  author={H{\'e}l{\`e}ne A Elicha Gussin and Ian D. Tomlinson and Deborah M. Little and Michael R. Warnement and Haohua Qian and Sandra J Rosenthal and David R. Pepperberg},
  journal={Journal of the American Chemical Society},
  volume={128 49},
Functionalization of highly fluorescent CdSe/ZnS core-shell nanocrystals (quantum dots, qdots) is an emerging technology for labeling cell surface proteins. We have synthesized a conjugate consisting of approximately 150-200 muscimols (a GABA receptor agonist) covalently joined to the qdot via a poly(ethylene glycol) (PEG) linker (approximately 78 ethylene glycol units) and investigated the binding of this muscimol-PEG-qdot conjugate to homomeric rho1 GABAC receptors expressed in Xenopus… CONTINUE READING
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