Binding of model soluble immune complexes to modified C-reactive protein.

  title={Binding of model soluble immune complexes to modified C-reactive protein.},
  author={M Motie and Susan L. Brockmeier and Lawrence Albert Potempa},
  journal={Journal of immunology},
  volume={156 11},
We have identified a binding interaction between a modified form of C-reactive protein (mCRP) and model immune complexes. We have characterized these interactions in terms of their relative affinity, specificity, pH dependence, and recognition site on mCRP. First, binding isotherms were generated for the reaction of immobilized mCRP with heat-aggregated IgG (HAG) which gave an estimate for the value of the dissociation constant, Kd, of 1.6 nM. Second, competitive binding assays were performed… CONTINUE READING

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