Binding of matrix attachment regions to nuclear lamin is mediated by the rod domain and depends on the lamin polymerization state.

Abstract

The nuclear matrix maintains specific interactions with genomic DNA at sites known as matrix attachment regions (M/SARs). M/SARs bind in vitro to lamin polymers. We show that the polymerized alpha-helical rod domain of lamin Dm0 provides by itself the specific binding to the ftz M/SAR. In contrast, unpolymerized rod domain does not bind specifically to this… (More)

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@article{Zhao1996BindingOM, title={Binding of matrix attachment regions to nuclear lamin is mediated by the rod domain and depends on the lamin polymerization state.}, author={K. Zhao and A. Harel and Nico Stuurman and Daniel Guedalia and Yosef Gruenbaum}, journal={FEBS letters}, year={1996}, volume={380 1-2}, pages={161-4} }