Binding of ligands and activation of transcription by nuclear receptors.

  title={Binding of ligands and activation of transcription by nuclear receptors.},
  author={Annin Steinmetz and J. P. Renaud and Dino Moras},
  journal={Annual review of biophysics and biomolecular structure},
Nuclear receptors (NRs) form a superfamily of ligand-inducible transcription factors composed of several domains. Recent structural studies focused on domain E, which harbors the ligand-binding site and the ligand-dependent transcription activation function AF-2. Structures of single representatives in an increasing number of various complexes as well as new structures of further NRs addressed issues such as discrimination of ligands, superagonism, isotype specificity, and partial agonism… CONTINUE READING


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