Binding of intracellular anti-Rev single chain variable fragments to different epitopes of human immunodeficiency virus type 1 rev: variations in viral inhibition.

@article{Wu1996BindingOI,
  title={Binding of intracellular anti-Rev single chain variable fragments to different epitopes of human immunodeficiency virus type 1 rev: variations in viral inhibition.},
  author={Y Wu and L X Duan and Mingzhu Zhu and Bugen Hu and Satoshi Kubota and Omar Bagasra and Roger J. Pomerantz},
  journal={Journal of virology},
  year={1996},
  volume={70 5},
  pages={3290-7}
}
Intracellular immunization to target the human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev has been explored as a genetic therapy for AIDS. Efficient intracellular expression of rearranged immunoglobulin heavy and light chain variable regions of anti-Rev monoclonal antibodies, with various vectors, and subsequent inhibition of HIV-1 replication have been previously reported by our laboratories. To further understand the molecular mechanisms and effects that intracellular anti… CONTINUE READING

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